Gene information
Official symbol APLN
Official full name apelin
Gene type protein-coding gene
ChromosomeXq26.1
Alias symbolapelin; XNPEP2
Gene familyNeuropeptides
Resources
Entrez Gene 8862
HGNC HGNC:16665
Ensembl ENSG00000171388
Vega OTTHUMG00000022371
UCSC uc004eus.4
GO terms: 52 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002090 regulation of receptor internalization GO Biological Processes -5.25557829 7 More
GO:0002092 positive regulation of receptor internalization GO Biological Processes -5.94640285 6 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0005179 hormone activity GO Molecular Functions -33.3562443 33 More
GO:0007369 gastrulation GO Biological Processes -9.78060849 28 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007589 body fluid secretion GO Biological Processes -11.5155091 20 More
GO:0007595 lactation GO Biological Processes -4.29648227 9 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007631 feeding behavior GO Biological Processes -8.63374021 12 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0030100 regulation of endocytosis GO Biological Processes -14.0757782 22 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway GO Biological Processes -4.66781085 9 More
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway GO Biological Processes -3.41852381 6 More
GO:0042756 drinking behavior GO Biological Processes -5.39331932 6 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045776 negative regulation of blood pressure GO Biological Processes -17.1357953 22 More
GO:0045807 positive regulation of endocytosis GO Biological Processes -11.0143833 14 More
GO:0045823 positive regulation of heart contraction GO Biological Processes -10.6953794 15 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048259 regulation of receptor-mediated endocytosis GO Biological Processes -11.3903749 15 More
GO:0048260 positive regulation of receptor-mediated endocytosis GO Biological Processes -10.1090317 11 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048662 negative regulation of smooth muscle cell proliferation GO Biological Processes -21.7509412 30 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0060976 coronary vasculature development GO Biological Processes -7.60302561 13 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0090288 negative regulation of cellular response to growth factor stimulus GO Biological Processes -9.39414218 23 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903524 positive regulation of blood circulation GO Biological Processes -11.6803256 16 More
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation GO Biological Processes -11.2917234 16 More
GO:1905564 positive regulation of vascular endothelial cell proliferation GO Biological Processes -12.8410298 14 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04371 Apelin signaling pathway KEGG Pathway -6.49715749 12 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
staurosporine NCI 12215493 view
Related studies: 13 records
Molecular factor Omics type Application Objective MI type Reference
NC_000023.11:g.[129656490A>G;129655744A>C;129653796C>T;129651324C>T;129648585G>T;129648435G>C;129652326T>C;129646415G>C] genomics myocardial infarction[diagnosis] myocardial infarction Li Y et al. Gene. 2021
apelin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Weir RA et al. Eur J Heart Fail. 2009
apelin proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ye J et al. J Biomed Res. 2012
apelin proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Liu HT et al. Medicine (Baltimore). 2015
apelin proteomics reduced left ventricular ejection fraction[prognosis (bad)] acute ST elevation myocardial infarction Shen J et al. Nan Fang Yi Ke Da Xue Xue Bao. 2015
apelin proteomics major adverse cardiovascular events[prognosis (bad)] ST elevation myocardial infarction Topuz M et al. Perfusion. 2017
apelin proteomics poor predictor death[prognosis (bad)] acute ST elevation myocardial infarction Sans-Rosello J et al. Clin Biochem. 2017
apelin proteomics good predictor myocardial reperfusion[prognosis (good)] acute ST elevation myocardial infarction Ying Z et al. Coron Artery Dis. 2019
NC_000023.11:g.129651324C>T genomics myocardial infarction[diagnosis] myocardial infarction Li Y et al. Gene. 2021
NC_000023.11:g.129652326T>C genomics myocardial infarction[diagnosis] myocardial infarction Li Y et al. Gene. 2021
NC_000023.11:g.129652326T>C genomics myocardial infarction[diagnosis] myocardial infarction Li Y et al. Gene. 2021
NC_000023.11:g.129656490A>G genomics myocardial infarction[diagnosis] myocardial infarction Li Y et al. Gene. 2021
NC_000023.11:g.129656490A>G genomics myocardial infarction[diagnosis] myocardial infarction Li Y et al. Gene. 2021
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